{
  "schema_version": "0.1.0",
  "id": "fda-drug-shortage:methylprednisolone-acetate-injection",
  "slug": "methylprednisolone-acetate-injection",
  "title": "FDA shortage status: Methylprednisolone Acetate Injection",
  "ingredient": "Methylprednisolone Acetate Injection",
  "status": "current",
  "source_statuses": [
    "Current"
  ],
  "brand_names": [
    "DEPO-MEDROL",
    "METHYLPREDNISOLONE ACETATE"
  ],
  "therapeutic_categories": [
    "Rheumatology"
  ],
  "dosage_forms": [
    "Injection"
  ],
  "routes": [
    "INTRA-ARTICULAR",
    "INTRALESIONAL",
    "INTRAMUSCULAR",
    "INTRASYNOVIAL",
    "SOFT TISSUE"
  ],
  "package_count": 23,
  "packages": [
    {
      "package_ndc": "70121-1573-1",
      "product_ndc": "70121-1573",
      "company_name": "Amneal Pharmaceuticals",
      "manufacturer_name": "Amneal Pharmaceuticals LLC",
      "presentation": "Methylprednisolone Acetate, Injection, 40 mg/1 mL (NDC 70121-1573-1)",
      "availability": "Limited Availability",
      "dosage_form": "Injection",
      "routes": [
        "INTRA-ARTICULAR",
        "INTRALESIONAL",
        "INTRAMUSCULAR",
        "INTRASYNOVIAL",
        "SOFT TISSUE"
      ],
      "update_date": "06/17/2026",
      "initial_posting_date": "12/15/2021",
      "source_url": "https://api.fda.gov/drug/shortages.json"
    },
    {
      "package_ndc": "70121-1573-5",
      "product_ndc": "70121-1573",
      "company_name": "Amneal Pharmaceuticals",
      "manufacturer_name": "Amneal Pharmaceuticals LLC",
      "presentation": "Methylprednisolone Acetate, Injection, 40 mg/1 mL (NDC 70121-1573-5)",
      "availability": "Available",
      "dosage_form": "Injection",
      "routes": [
        "INTRA-ARTICULAR",
        "INTRALESIONAL",
        "INTRAMUSCULAR",
        "INTRASYNOVIAL",
        "SOFT TISSUE"
      ],
      "update_date": "06/17/2026",
      "initial_posting_date": "12/15/2021",
      "source_url": "https://api.fda.gov/drug/shortages.json"
    },
    {
      "package_ndc": "70121-1574-1",
      "product_ndc": "70121-1573",
      "company_name": "Amneal Pharmaceuticals",
      "manufacturer_name": "Amneal Pharmaceuticals LLC",
      "presentation": "Methylprednisolone Acetate, Injection, 80 mg/1 mL (NDC 70121-1574-1)",
      "availability": "Available",
      "dosage_form": "Injection",
      "routes": [
        "INTRA-ARTICULAR",
        "INTRALESIONAL",
        "INTRAMUSCULAR",
        "SOFT TISSUE"
      ],
      "update_date": "06/17/2026",
      "initial_posting_date": "12/15/2021",
      "source_url": "https://api.fda.gov/drug/shortages.json"
    },
    {
      "package_ndc": "70121-1574-5",
      "product_ndc": "70121-1573",
      "company_name": "Amneal Pharmaceuticals",
      "manufacturer_name": "Amneal Pharmaceuticals LLC",
      "presentation": "Methylprednisolone Acetate, Injection, 80 mg/1 mL (NDC 70121-1574-5)",
      "availability": "Available",
      "dosage_form": "Injection",
      "routes": [
        "INTRA-ARTICULAR",
        "INTRALESIONAL",
        "INTRAMUSCULAR",
        "SOFT TISSUE"
      ],
      "update_date": "06/17/2026",
      "initial_posting_date": "12/15/2021",
      "source_url": "https://api.fda.gov/drug/shortages.json"
    },
    {
      "package_ndc": "55150-313-01",
      "product_ndc": "55150-313",
      "company_name": "Eugia US LLC",
      "manufacturer_name": "Eugia US LLC",
      "presentation": "Methylprednisolone Acetate, Injection, 40 mg/1 mL (NDC 55150-313-01)",
      "availability": "Unavailable",
      "dosage_form": "Injection",
      "routes": [
        "INTRA-ARTICULAR",
        "INTRALESIONAL",
        "INTRAMUSCULAR",
        "SOFT TISSUE"
      ],
      "update_date": "08/06/2026",
      "initial_posting_date": "12/15/2021",
      "source_url": "https://api.fda.gov/drug/shortages.json"
    },
    {
      "package_ndc": "55150-314-01",
      "product_ndc": "55150-313",
      "company_name": "Eugia US LLC",
      "manufacturer_name": "Eugia US LLC",
      "presentation": "Methylprednisolone Acetate, Injection, 80 mg/1 mL (NDC 55150-314-01)",
      "availability": "Unavailable",
      "dosage_form": "Injection",
      "routes": [
        "INTRA-ARTICULAR",
        "INTRALESIONAL",
        "INTRAMUSCULAR",
        "SOFT TISSUE"
      ],
      "update_date": "08/06/2026",
      "initial_posting_date": "12/15/2021",
      "source_url": "https://api.fda.gov/drug/shortages.json"
    },
    {
      "package_ndc": "42023-240-01",
      "product_ndc": null,
      "company_name": "Par Health, USA LLC",
      "manufacturer_name": null,
      "presentation": "Methylprednisolone Acetate, Injection, 80 mg/1 mL (NDC 42023-240-01)",
      "availability": "Unavailable",
      "dosage_form": "Injection",
      "routes": [],
      "update_date": "08/18/2026",
      "initial_posting_date": "06/16/2022",
      "source_url": "https://api.fda.gov/drug/shortages.json"
    },
    {
      "package_ndc": "0009-0274-01",
      "product_ndc": "0009-0274",
      "company_name": "Pfizer Inc.",
      "manufacturer_name": "Pharmacia & Upjohn Company LLC",
      "presentation": "Depo-medrol, Injection, 20 mg/1 mL (NDC 0009-0274-01)",
      "availability": "Available",
      "dosage_form": "Injection",
      "routes": [
        "INTRALESIONAL",
        "INTRAMUSCULAR",
        "INTRASYNOVIAL",
        "SOFT TISSUE"
      ],
      "update_date": "08/07/2026",
      "initial_posting_date": "12/15/2021",
      "source_url": "https://api.fda.gov/drug/shortages.json"
    },
    {
      "package_ndc": "0009-0280-02",
      "product_ndc": "0009-0274",
      "company_name": "Pfizer Inc.",
      "manufacturer_name": "Pharmacia & Upjohn Company LLC",
      "presentation": "Depo-medrol, Injection, 40 mg/1 mL (NDC 0009-0280-02)",
      "availability": "Available",
      "dosage_form": "Injection",
      "routes": [
        "INTRALESIONAL",
        "INTRAMUSCULAR",
        "INTRASYNOVIAL",
        "SOFT TISSUE"
      ],
      "update_date": "08/07/2026",
      "initial_posting_date": "12/15/2021",
      "source_url": "https://api.fda.gov/drug/shortages.json"
    },
    {
      "package_ndc": "0009-0280-03",
      "product_ndc": "0009-0274",
      "company_name": "Pfizer Inc.",
      "manufacturer_name": "Pharmacia & Upjohn Company LLC",
      "presentation": "Depo-medrol, Injection, 40 mg/1 mL (NDC 0009-0280-03)",
      "availability": "Limited Availability",
      "dosage_form": "Injection",
      "routes": [
        "INTRALESIONAL",
        "INTRAMUSCULAR",
        "INTRASYNOVIAL",
        "SOFT TISSUE"
      ],
      "update_date": "08/07/2026",
      "initial_posting_date": "12/15/2021",
      "source_url": "https://api.fda.gov/drug/shortages.json"
    },
    {
      "package_ndc": "0009-0280-51",
      "product_ndc": "0009-0274",
      "company_name": "Pfizer Inc.",
      "manufacturer_name": "Pharmacia & Upjohn Company LLC",
      "presentation": "Depo-medrol, Injection, 40 mg/1 mL (NDC 0009-0280-51)",
      "availability": "Available",
      "dosage_form": "Injection",
      "routes": [
        "INTRALESIONAL",
        "INTRAMUSCULAR",
        "INTRASYNOVIAL",
        "SOFT TISSUE"
      ],
      "update_date": "08/07/2026",
      "initial_posting_date": "12/15/2021",
      "source_url": "https://api.fda.gov/drug/shortages.json"
    },
    {
      "package_ndc": "0009-0280-52",
      "product_ndc": "0009-0274",
      "company_name": "Pfizer Inc.",
      "manufacturer_name": "Pharmacia & Upjohn Company LLC",
      "presentation": "Depo-medrol, Injection, 40 mg/1 mL (NDC 0009-0280-52)",
      "availability": "Available",
      "dosage_form": "Injection",
      "routes": [
        "INTRALESIONAL",
        "INTRAMUSCULAR",
        "INTRASYNOVIAL",
        "SOFT TISSUE"
      ],
      "update_date": "08/07/2026",
      "initial_posting_date": "12/15/2021",
      "source_url": "https://api.fda.gov/drug/shortages.json"
    },
    {
      "package_ndc": "0009-3073-01",
      "product_ndc": "0009-3073",
      "company_name": "Pfizer Inc.",
      "manufacturer_name": "Pharmacia & Upjohn Company LLC",
      "presentation": "Depo-medrol, Injection, 40 mg/1 mL (NDC 0009-3073-01)",
      "availability": "Limited Availability",
      "dosage_form": "Injection",
      "routes": [
        "INTRA-ARTICULAR",
        "INTRALESIONAL",
        "INTRAMUSCULAR",
        "INTRASYNOVIAL",
        "SOFT TISSUE"
      ],
      "update_date": "08/07/2026",
      "initial_posting_date": "12/15/2021",
      "source_url": "https://api.fda.gov/drug/shortages.json"
    },
    {
      "package_ndc": "0009-3073-03",
      "product_ndc": "0009-3073",
      "company_name": "Pfizer Inc.",
      "manufacturer_name": "Pharmacia & Upjohn Company LLC",
      "presentation": "Depo-medrol, Injection, 40 mg/1 mL (NDC 0009-3073-03)",
      "availability": "Limited Availability",
      "dosage_form": "Injection",
      "routes": [
        "INTRA-ARTICULAR",
        "INTRALESIONAL",
        "INTRAMUSCULAR",
        "INTRASYNOVIAL",
        "SOFT TISSUE"
      ],
      "update_date": "08/07/2026",
      "initial_posting_date": "12/15/2021",
      "source_url": "https://api.fda.gov/drug/shortages.json"
    },
    {
      "package_ndc": "0009-3073-22",
      "product_ndc": "0009-3073",
      "company_name": "Pfizer Inc.",
      "manufacturer_name": "Pharmacia & Upjohn Company LLC",
      "presentation": "Depo-medrol, Injection, 40 mg/1 mL (NDC 0009-3073-22)",
      "availability": "Unavailable",
      "dosage_form": "Injection",
      "routes": [
        "INTRA-ARTICULAR",
        "INTRALESIONAL",
        "INTRAMUSCULAR",
        "INTRASYNOVIAL",
        "SOFT TISSUE"
      ],
      "update_date": "08/07/2026",
      "initial_posting_date": "12/15/2021",
      "source_url": "https://api.fda.gov/drug/shortages.json"
    },
    {
      "package_ndc": "0009-3073-23",
      "product_ndc": "0009-3073",
      "company_name": "Pfizer Inc.",
      "manufacturer_name": "Pharmacia & Upjohn Company LLC",
      "presentation": "Depo-medrol, Injection, 40 mg/1 mL (NDC 0009-3073-23)",
      "availability": "Limited Availability",
      "dosage_form": "Injection",
      "routes": [
        "INTRA-ARTICULAR",
        "INTRALESIONAL",
        "INTRAMUSCULAR",
        "INTRASYNOVIAL",
        "SOFT TISSUE"
      ],
      "update_date": "08/07/2026",
      "initial_posting_date": "12/15/2021",
      "source_url": "https://api.fda.gov/drug/shortages.json"
    },
    {
      "package_ndc": "0009-0306-02",
      "product_ndc": "0009-0274",
      "company_name": "Pfizer Inc.",
      "manufacturer_name": "Pharmacia & Upjohn Company LLC",
      "presentation": "Depo-medrol, Injection, 80 mg/1 mL (NDC 0009-0306-02)",
      "availability": "Available",
      "dosage_form": "Injection",
      "routes": [
        "INTRALESIONAL",
        "INTRAMUSCULAR",
        "INTRASYNOVIAL",
        "SOFT TISSUE"
      ],
      "update_date": "08/07/2026",
      "initial_posting_date": "12/15/2021",
      "source_url": "https://api.fda.gov/drug/shortages.json"
    },
    {
      "package_ndc": "0009-0306-12",
      "product_ndc": "0009-0274",
      "company_name": "Pfizer Inc.",
      "manufacturer_name": "Pharmacia & Upjohn Company LLC",
      "presentation": "Depo-medrol, Injection, 80 mg/1 mL (NDC 0009-0306-12)",
      "availability": "Available",
      "dosage_form": "Injection",
      "routes": [
        "INTRALESIONAL",
        "INTRAMUSCULAR",
        "INTRASYNOVIAL",
        "SOFT TISSUE"
      ],
      "update_date": "08/07/2026",
      "initial_posting_date": "12/15/2021",
      "source_url": "https://api.fda.gov/drug/shortages.json"
    },
    {
      "package_ndc": "0009-3475-01",
      "product_ndc": "0009-3073",
      "company_name": "Pfizer Inc.",
      "manufacturer_name": "Pharmacia & Upjohn Company LLC",
      "presentation": "Depo-medrol, Injection, 80 mg/1 mL (NDC 0009-3475-01)",
      "availability": "Limited Availability",
      "dosage_form": "Injection",
      "routes": [
        "INTRA-ARTICULAR",
        "INTRALESIONAL",
        "INTRAMUSCULAR",
        "SOFT TISSUE"
      ],
      "update_date": "08/07/2026",
      "initial_posting_date": "12/15/2021",
      "source_url": "https://api.fda.gov/drug/shortages.json"
    },
    {
      "package_ndc": "0009-3475-03",
      "product_ndc": "0009-3073",
      "company_name": "Pfizer Inc.",
      "manufacturer_name": "Pharmacia & Upjohn Company LLC",
      "presentation": "Depo-medrol, Injection, 80 mg/1 mL (NDC 0009-3475-03)",
      "availability": "Available",
      "dosage_form": "Injection",
      "routes": [
        "INTRA-ARTICULAR",
        "INTRALESIONAL",
        "INTRAMUSCULAR",
        "SOFT TISSUE"
      ],
      "update_date": "08/07/2026",
      "initial_posting_date": "12/15/2021",
      "source_url": "https://api.fda.gov/drug/shortages.json"
    },
    {
      "package_ndc": "25021-820-05",
      "product_ndc": "25021-820",
      "company_name": "Sagent Pharmaceuticals",
      "manufacturer_name": "Sagent Pharmaceuticals",
      "presentation": "Methylprednisolone Acetate, Injection, 40 mg/1 mL (NDC 25021-820-05)",
      "availability": "Unavailable",
      "dosage_form": "Injection",
      "routes": [
        "INTRA-ARTICULAR",
        "INTRALESIONAL",
        "INTRAMUSCULAR",
        "INTRASYNOVIAL",
        "SOFT TISSUE"
      ],
      "update_date": "08/18/2026",
      "initial_posting_date": "12/15/2021",
      "source_url": "https://api.fda.gov/drug/shortages.json"
    },
    {
      "package_ndc": "25021-820-10",
      "product_ndc": "25021-820",
      "company_name": "Sagent Pharmaceuticals",
      "manufacturer_name": "Sagent Pharmaceuticals",
      "presentation": "Methylprednisolone Acetate, Injection, 40 mg/1 mL (NDC 25021-820-10)",
      "availability": "Unavailable",
      "dosage_form": "Injection",
      "routes": [
        "INTRA-ARTICULAR",
        "INTRALESIONAL",
        "INTRAMUSCULAR",
        "INTRASYNOVIAL",
        "SOFT TISSUE"
      ],
      "update_date": "08/18/2026",
      "initial_posting_date": "12/15/2021",
      "source_url": "https://api.fda.gov/drug/shortages.json"
    },
    {
      "package_ndc": "25021-821-05",
      "product_ndc": "25021-820",
      "company_name": "Sagent Pharmaceuticals",
      "manufacturer_name": "Sagent Pharmaceuticals",
      "presentation": "Methylprednisolone Acetate, Injection, 80 mg/1 mL (NDC 25021-821-05)",
      "availability": "Limited Availability",
      "dosage_form": "Injection",
      "routes": [
        "INTRA-ARTICULAR",
        "INTRALESIONAL",
        "INTRAMUSCULAR",
        "INTRASYNOVIAL",
        "SOFT TISSUE"
      ],
      "update_date": "08/18/2026",
      "initial_posting_date": "12/15/2021",
      "source_url": "https://api.fda.gov/drug/shortages.json"
    }
  ],
  "availability_counts": {
    "Available": 10,
    "Limited Availability": 7,
    "Unavailable": 6
  },
  "initial_posting_date": "06/16/2022",
  "latest_source_update": "08/18/2026",
  "source_updated_at": "2026-08-22",
  "official_url": "https://api.fda.gov/drug/shortages.json",
  "source_name": "U.S. Food and Drug Administration openFDA Drug Shortages",
  "source_license_url": "https://open.fda.gov/license/",
  "retrieved_at": "2026-08-22T15:54:11+00:00",
  "unknowns": {
    "local_availability": "Unknown. FDA status is nationwide and is not local inventory.",
    "clinical_alternatives": "Not provided. CiteFacts does not publish treatment or substitution advice.",
    "resolution_date": "Unknown unless an FDA source row provides an update date."
  },
  "derivations": {
    "status": "current when a grouped FDA row has Current; otherwise it preserves the available FDA Resolved, Discontinuation, or not-current state.",
    "ingredient_page": "Grouped by FDA generic_name, falling back to openFDA.generic_name.",
    "availability_counts": "Count of non-empty FDA package availability values; it is not a claim about local supply."
  }
}