{
  "schema_version": "0.1.0",
  "id": "fda-drug-shortage:epinephrine-bitartrate-lidocaine-hydrochloride-injection",
  "slug": "epinephrine-bitartrate-lidocaine-hydrochloride-injection",
  "title": "FDA shortage status: Epinephrine Bitartrate, Lidocaine Hydrochloride Injection",
  "ingredient": "Epinephrine Bitartrate, Lidocaine Hydrochloride Injection",
  "status": "current",
  "source_statuses": [
    "Current"
  ],
  "brand_names": [
    "LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE",
    "XYLOCAINE",
    "XYLOCAINE MPF"
  ],
  "therapeutic_categories": [
    "Anesthesia",
    "Pediatric"
  ],
  "dosage_forms": [
    "Injection"
  ],
  "routes": [
    "EPIDURAL",
    "INFILTRATION",
    "INTRACAUDAL",
    "PERINEURAL"
  ],
  "package_count": 22,
  "packages": [
    {
      "package_ndc": "63323-487-17",
      "product_ndc": "63323-481",
      "company_name": "Fresenius Kabi USA, LLC",
      "manufacturer_name": "Fresenius Kabi USA, LLC",
      "presentation": "Xylocaine, Injection, .005 mg/1 mL; 10 mg/1 mL (NDC 63323-487-17)",
      "availability": "Available",
      "dosage_form": "Injection",
      "routes": [
        "EPIDURAL",
        "INFILTRATION",
        "INTRACAUDAL",
        "PERINEURAL"
      ],
      "update_date": "08/04/2026",
      "initial_posting_date": "10/14/2016",
      "source_url": "https://api.fda.gov/drug/shortages.json"
    },
    {
      "package_ndc": "63323-487-37",
      "product_ndc": "63323-481",
      "company_name": "Fresenius Kabi USA, LLC",
      "manufacturer_name": "Fresenius Kabi USA, LLC",
      "presentation": "Xylocaine, Injection, .005 mg/1 mL; 10 mg/1 mL (NDC 63323-487-37)",
      "availability": "Available",
      "dosage_form": "Injection",
      "routes": [
        "EPIDURAL",
        "INFILTRATION",
        "INTRACAUDAL",
        "PERINEURAL"
      ],
      "update_date": "08/04/2026",
      "initial_posting_date": "10/14/2016",
      "source_url": "https://api.fda.gov/drug/shortages.json"
    },
    {
      "package_ndc": "63323-488-17",
      "product_ndc": "63323-481",
      "company_name": "Fresenius Kabi USA, LLC",
      "manufacturer_name": "Fresenius Kabi USA, LLC",
      "presentation": "Xylocaine, Injection, .005 mg/1 mL; 15 mg/1 mL (NDC 63323-488-17)",
      "availability": "Available",
      "dosage_form": "Injection",
      "routes": [
        "EPIDURAL",
        "INFILTRATION",
        "INTRACAUDAL",
        "PERINEURAL"
      ],
      "update_date": "08/04/2026",
      "initial_posting_date": "10/14/2016",
      "source_url": "https://api.fda.gov/drug/shortages.json"
    },
    {
      "package_ndc": "63323-488-37",
      "product_ndc": "63323-481",
      "company_name": "Fresenius Kabi USA, LLC",
      "manufacturer_name": "Fresenius Kabi USA, LLC",
      "presentation": "Xylocaine, Injection, .005 mg/1 mL; 15 mg/1 mL (NDC 63323-488-37)",
      "availability": "Available",
      "dosage_form": "Injection",
      "routes": [
        "EPIDURAL",
        "INFILTRATION",
        "INTRACAUDAL",
        "PERINEURAL"
      ],
      "update_date": "08/04/2026",
      "initial_posting_date": "10/14/2016",
      "source_url": "https://api.fda.gov/drug/shortages.json"
    },
    {
      "package_ndc": "63323-489-17",
      "product_ndc": "63323-481",
      "company_name": "Fresenius Kabi USA, LLC",
      "manufacturer_name": "Fresenius Kabi USA, LLC",
      "presentation": "Xylocaine, Injection, .005 mg/1 mL; 20 mg/1 mL (NDC 63323-489-17)",
      "availability": "Available",
      "dosage_form": "Injection",
      "routes": [
        "EPIDURAL",
        "INFILTRATION",
        "INTRACAUDAL",
        "PERINEURAL"
      ],
      "update_date": "08/04/2026",
      "initial_posting_date": "10/14/2016",
      "source_url": "https://api.fda.gov/drug/shortages.json"
    },
    {
      "package_ndc": "63323-489-27",
      "product_ndc": "63323-481",
      "company_name": "Fresenius Kabi USA, LLC",
      "manufacturer_name": "Fresenius Kabi USA, LLC",
      "presentation": "Xylocaine, Injection, .005 mg/1 mL; 20 mg/1 mL (NDC 63323-489-27)",
      "availability": "Unavailable",
      "dosage_form": "Injection",
      "routes": [
        "EPIDURAL",
        "INFILTRATION",
        "INTRACAUDAL",
        "PERINEURAL"
      ],
      "update_date": "08/04/2026",
      "initial_posting_date": "10/14/2016",
      "source_url": "https://api.fda.gov/drug/shortages.json"
    },
    {
      "package_ndc": "63323-481-57",
      "product_ndc": "63323-481",
      "company_name": "Fresenius Kabi USA, LLC",
      "manufacturer_name": "Fresenius Kabi USA, LLC",
      "presentation": "Xylocaine, Injection, .005 mg/1 mL; 5 mg/1 mL (NDC 63323-481-57)",
      "availability": "Available",
      "dosage_form": "Injection",
      "routes": [
        "INFILTRATION",
        "PERINEURAL"
      ],
      "update_date": "08/04/2026",
      "initial_posting_date": "10/14/2016",
      "source_url": "https://api.fda.gov/drug/shortages.json"
    },
    {
      "package_ndc": "63323-482-17",
      "product_ndc": "63323-481",
      "company_name": "Fresenius Kabi USA, LLC",
      "manufacturer_name": "Fresenius Kabi USA, LLC",
      "presentation": "Xylocaine, Injection, .01 mg/1 mL; 10 mg/1 mL (NDC 63323-482-17)",
      "availability": "Available",
      "dosage_form": "Injection",
      "routes": [
        "INFILTRATION",
        "PERINEURAL"
      ],
      "update_date": "08/04/2026",
      "initial_posting_date": "10/14/2016",
      "source_url": "https://api.fda.gov/drug/shortages.json"
    },
    {
      "package_ndc": "63323-482-27",
      "product_ndc": "63323-481",
      "company_name": "Fresenius Kabi USA, LLC",
      "manufacturer_name": "Fresenius Kabi USA, LLC",
      "presentation": "Xylocaine, Injection, .01 mg/1 mL; 10 mg/1 mL (NDC 63323-482-27)",
      "availability": "Available",
      "dosage_form": "Injection",
      "routes": [
        "INFILTRATION",
        "PERINEURAL"
      ],
      "update_date": "08/04/2026",
      "initial_posting_date": "10/14/2016",
      "source_url": "https://api.fda.gov/drug/shortages.json"
    },
    {
      "package_ndc": "63323-482-57",
      "product_ndc": "63323-481",
      "company_name": "Fresenius Kabi USA, LLC",
      "manufacturer_name": "Fresenius Kabi USA, LLC",
      "presentation": "Xylocaine, Injection, .01 mg/1 mL; 10 mg/1 mL (NDC 63323-482-57)",
      "availability": "Unavailable",
      "dosage_form": "Injection",
      "routes": [
        "INFILTRATION",
        "PERINEURAL"
      ],
      "update_date": "08/04/2026",
      "initial_posting_date": "10/14/2016",
      "source_url": "https://api.fda.gov/drug/shortages.json"
    },
    {
      "package_ndc": "63323-483-27",
      "product_ndc": "63323-481",
      "company_name": "Fresenius Kabi USA, LLC",
      "manufacturer_name": "Fresenius Kabi USA, LLC",
      "presentation": "Xylocaine, Injection, .01 mg/1 mL; 20 mg/1 mL (NDC 63323-483-27)",
      "availability": "Available",
      "dosage_form": "Injection",
      "routes": [
        "INFILTRATION",
        "PERINEURAL"
      ],
      "update_date": "08/04/2026",
      "initial_posting_date": "10/14/2016",
      "source_url": "https://api.fda.gov/drug/shortages.json"
    },
    {
      "package_ndc": "63323-483-57",
      "product_ndc": "63323-481",
      "company_name": "Fresenius Kabi USA, LLC",
      "manufacturer_name": "Fresenius Kabi USA, LLC",
      "presentation": "Xylocaine, Injection, .01 mg/1 mL; 20 mg/1 mL (NDC 63323-483-57)",
      "availability": "Available",
      "dosage_form": "Injection",
      "routes": [
        "INFILTRATION",
        "PERINEURAL"
      ],
      "update_date": "08/04/2026",
      "initial_posting_date": "10/14/2016",
      "source_url": "https://api.fda.gov/drug/shortages.json"
    },
    {
      "package_ndc": "0409-3182-03",
      "product_ndc": "0409-0007",
      "company_name": "Hospira, Inc., a Pfizer Company",
      "manufacturer_name": "Hospira, Inc.",
      "presentation": "Lidocaine Hydrochloride And Epinephrine, Injection, 1 g/50 mL (2%; 1:100,000) (NDC 0409-3182-03)",
      "availability": "Limited Availability",
      "dosage_form": "Injection",
      "routes": [
        "INFILTRATION",
        "PERINEURAL"
      ],
      "update_date": "08/07/2026",
      "initial_posting_date": "02/22/2012",
      "source_url": "https://api.fda.gov/drug/shortages.json"
    },
    {
      "package_ndc": "0409-3177-01",
      "product_ndc": "0409-0007",
      "company_name": "Hospira, Inc., a Pfizer Company",
      "manufacturer_name": "Hospira, Inc.",
      "presentation": "Lidocaine Hydrochloride And Epinephrine, Injection, 2.5 g/50 mL (0.5%; 1:200,000) (NDC 0409-3177-01)",
      "availability": "Unavailable",
      "dosage_form": "Injection",
      "routes": [
        "INFILTRATION",
        "PERINEURAL"
      ],
      "update_date": "08/07/2026",
      "initial_posting_date": "02/22/2012",
      "source_url": "https://api.fda.gov/drug/shortages.json"
    },
    {
      "package_ndc": "0409-3178-01",
      "product_ndc": "0409-0007",
      "company_name": "Hospira, Inc., a Pfizer Company",
      "manufacturer_name": "Hospira, Inc.",
      "presentation": "Lidocaine Hydrochloride And Epinephrine, Injection, 200 mg/20 mL (1%; 1:100,000) (NDC 0409-3178-01)",
      "availability": "Limited Availability",
      "dosage_form": "Injection",
      "routes": [
        "INFILTRATION",
        "PERINEURAL"
      ],
      "update_date": "08/07/2026",
      "initial_posting_date": "02/22/2012",
      "source_url": "https://api.fda.gov/drug/shortages.json"
    },
    {
      "package_ndc": "0409-3178-02",
      "product_ndc": "0409-0007",
      "company_name": "Hospira, Inc., a Pfizer Company",
      "manufacturer_name": "Hospira, Inc.",
      "presentation": "Lidocaine Hydrochloride And Epinephrine, Injection, 300 mg/30 mL (1%; 1:100,000) (NDC 0409-3178-02)",
      "availability": "Unavailable",
      "dosage_form": "Injection",
      "routes": [
        "INFILTRATION",
        "PERINEURAL"
      ],
      "update_date": "08/07/2026",
      "initial_posting_date": "02/22/2012",
      "source_url": "https://api.fda.gov/drug/shortages.json"
    },
    {
      "package_ndc": "0409-3182-01",
      "product_ndc": "0409-0007",
      "company_name": "Hospira, Inc., a Pfizer Company",
      "manufacturer_name": "Hospira, Inc.",
      "presentation": "Lidocaine Hydrochloride And Epinephrine, Injection, 400 mg/20 mL (2%; 1:100,000) (NDC 0409-3182-01)",
      "availability": "Unavailable",
      "dosage_form": "Injection",
      "routes": [
        "INFILTRATION",
        "PERINEURAL"
      ],
      "update_date": "08/07/2026",
      "initial_posting_date": "02/22/2012",
      "source_url": "https://api.fda.gov/drug/shortages.json"
    },
    {
      "package_ndc": "0409-3183-01",
      "product_ndc": "0409-0007",
      "company_name": "Hospira, Inc., a Pfizer Company",
      "manufacturer_name": "Hospira, Inc.",
      "presentation": "Lidocaine Hydrochloride And Epinephrine, Injection, 400 mg/20 mL (2%; 1:200,000) (NDC 0409-3183-01)",
      "availability": "Limited Availability",
      "dosage_form": "Injection",
      "routes": [
        "EPIDURAL",
        "INFILTRATION",
        "INTRACAUDAL",
        "PERINEURAL"
      ],
      "update_date": "08/07/2026",
      "initial_posting_date": "02/22/2012",
      "source_url": "https://api.fda.gov/drug/shortages.json"
    },
    {
      "package_ndc": "0409-3181-01",
      "product_ndc": "0409-0007",
      "company_name": "Hospira, Inc., a Pfizer Company",
      "manufacturer_name": "Hospira, Inc.",
      "presentation": "Lidocaine Hydrochloride And Epinephrine, Injection, 450 mg/30 mL (1.5%; 1:200,000) (NDC 0409-3181-01)",
      "availability": "Available",
      "dosage_form": "Injection",
      "routes": [
        "EPIDURAL",
        "INFILTRATION",
        "INTRACAUDAL",
        "PERINEURAL"
      ],
      "update_date": "08/07/2026",
      "initial_posting_date": "02/22/2012",
      "source_url": "https://api.fda.gov/drug/shortages.json"
    },
    {
      "package_ndc": "0409-3178-03",
      "product_ndc": "0409-0007",
      "company_name": "Hospira, Inc., a Pfizer Company",
      "manufacturer_name": "Hospira, Inc.",
      "presentation": "Lidocaine Hydrochloride And Epinephrine, Injection, 500 mg/50 mL (1%; 1:100,000) (NDC 0409-3178-03)",
      "availability": "Available",
      "dosage_form": "Injection",
      "routes": [
        "INFILTRATION",
        "PERINEURAL"
      ],
      "update_date": "08/07/2026",
      "initial_posting_date": "02/22/2012",
      "source_url": "https://api.fda.gov/drug/shortages.json"
    },
    {
      "package_ndc": "0409-1209-01",
      "product_ndc": "0409-0007",
      "company_name": "Hospira, Inc., a Pfizer Company",
      "manufacturer_name": "Hospira, Inc.",
      "presentation": "Lidocaine Hydrochloride And Epinephrine, Injection, 75 mg/5 mL (1.5%; 1:200,000) (NDC 0409-1209-01)",
      "availability": "Unavailable",
      "dosage_form": "Injection",
      "routes": [
        "EPIDURAL"
      ],
      "update_date": "08/07/2026",
      "initial_posting_date": "02/22/2012",
      "source_url": "https://api.fda.gov/drug/shortages.json"
    },
    {
      "package_ndc": "0409-3182-02",
      "product_ndc": "0409-0007",
      "company_name": "Hospira, Inc., a Pfizer Company",
      "manufacturer_name": "Hospira, Inc.",
      "presentation": "Lidocaine Hydrochloride and Epinephrine, Injection, 600 mg/30 mL (2%; 1:100,000) (NDC 0409-3182-02)",
      "availability": "Limited Availability",
      "dosage_form": "Injection",
      "routes": [
        "INFILTRATION",
        "PERINEURAL"
      ],
      "update_date": "08/07/2026",
      "initial_posting_date": "02/22/2012",
      "source_url": "https://api.fda.gov/drug/shortages.json"
    }
  ],
  "availability_counts": {
    "Available": 12,
    "Limited Availability": 4,
    "Unavailable": 6
  },
  "initial_posting_date": "02/22/2012",
  "latest_source_update": "08/07/2026",
  "source_updated_at": "2026-08-22",
  "official_url": "https://api.fda.gov/drug/shortages.json",
  "source_name": "U.S. Food and Drug Administration openFDA Drug Shortages",
  "source_license_url": "https://open.fda.gov/license/",
  "retrieved_at": "2026-08-22T15:54:11+00:00",
  "unknowns": {
    "local_availability": "Unknown. FDA status is nationwide and is not local inventory.",
    "clinical_alternatives": "Not provided. CiteFacts does not publish treatment or substitution advice.",
    "resolution_date": "Unknown unless an FDA source row provides an update date."
  },
  "derivations": {
    "status": "current when a grouped FDA row has Current; otherwise it preserves the available FDA Resolved, Discontinuation, or not-current state.",
    "ingredient_page": "Grouped by FDA generic_name, falling back to openFDA.generic_name.",
    "availability_counts": "Count of non-empty FDA package availability values; it is not a claim about local supply."
  }
}