{
  "schema_version": "0.1.0",
  "id": "fda-drug-shortage:bupivacaine-hydrochloride-epinephrine-bitartrate-injection",
  "slug": "bupivacaine-hydrochloride-epinephrine-bitartrate-injection",
  "title": "FDA shortage status: Bupivacaine Hydrochloride, Epinephrine Bitartrate Injection",
  "ingredient": "Bupivacaine Hydrochloride, Epinephrine Bitartrate Injection",
  "status": "current",
  "source_statuses": [
    "Current"
  ],
  "brand_names": [
    "BUPIVACAINE HYDROCHLORIDE AND EPINEPHRINE",
    "MARCAINE WITH EPINEPHRINE",
    "SENSORCAINE",
    "SENSORCAINE MPF"
  ],
  "therapeutic_categories": [
    "Anesthesia"
  ],
  "dosage_forms": [
    "Injection"
  ],
  "routes": [
    "EPIDURAL",
    "INFILTRATION",
    "INTRACAUDAL",
    "PERINEURAL",
    "RETROBULBAR"
  ],
  "package_count": 20,
  "packages": [
    {
      "package_ndc": "63323-461-57",
      "product_ndc": "63323-461",
      "company_name": "Fresenius Kabi USA, LLC",
      "manufacturer_name": "Fresenius Kabi USA, LLC",
      "presentation": "Sensorcaine, Injection, 2.5 mg/1 mL; .005 mg/1 mL (NDC 63323-461-57)",
      "availability": "Available",
      "dosage_form": "Injection",
      "routes": [
        "INFILTRATION",
        "PERINEURAL"
      ],
      "update_date": "08/04/2026",
      "initial_posting_date": "02/20/2018",
      "source_url": "https://api.fda.gov/drug/shortages.json"
    },
    {
      "package_ndc": "63323-468-17",
      "product_ndc": "63323-461",
      "company_name": "Fresenius Kabi USA, LLC",
      "manufacturer_name": "Fresenius Kabi USA, LLC",
      "presentation": "Sensorcaine, Injection, 2.5 mg/1 mL; .005 mg/1 mL (NDC 63323-468-17)",
      "availability": "Available",
      "dosage_form": "Injection",
      "routes": [
        "EPIDURAL",
        "INFILTRATION",
        "INTRACAUDAL",
        "PERINEURAL"
      ],
      "update_date": "08/04/2026",
      "initial_posting_date": "02/20/2018",
      "source_url": "https://api.fda.gov/drug/shortages.json"
    },
    {
      "package_ndc": "63323-468-37",
      "product_ndc": "63323-461",
      "company_name": "Fresenius Kabi USA, LLC",
      "manufacturer_name": "Fresenius Kabi USA, LLC",
      "presentation": "Sensorcaine, Injection, 2.5 mg/1 mL; .005 mg/1 mL (NDC 63323-468-37)",
      "availability": "Unavailable",
      "dosage_form": "Injection",
      "routes": [
        "EPIDURAL",
        "INFILTRATION",
        "INTRACAUDAL",
        "PERINEURAL"
      ],
      "update_date": "08/04/2026",
      "initial_posting_date": "02/20/2018",
      "source_url": "https://api.fda.gov/drug/shortages.json"
    },
    {
      "package_ndc": "63323-462-17",
      "product_ndc": "63323-460",
      "company_name": "Fresenius Kabi USA, LLC",
      "manufacturer_name": "Fresenius Kabi USA, LLC",
      "presentation": "Sensorcaine, Injection, 5 mg/1 mL; .005 mg/1 mL (NDC 63323-462-17)",
      "availability": "Available",
      "dosage_form": "Injection",
      "routes": [
        "EPIDURAL",
        "INFILTRATION",
        "INTRACAUDAL",
        "PERINEURAL"
      ],
      "update_date": "08/04/2026",
      "initial_posting_date": "02/20/2018",
      "source_url": "https://api.fda.gov/drug/shortages.json"
    },
    {
      "package_ndc": "63323-462-31",
      "product_ndc": "63323-460",
      "company_name": "Fresenius Kabi USA, LLC",
      "manufacturer_name": "Fresenius Kabi USA, LLC",
      "presentation": "Sensorcaine, Injection, 5 mg/1 mL; .005 mg/1 mL (NDC 63323-462-31)",
      "availability": "Unavailable",
      "dosage_form": "Injection",
      "routes": [
        "EPIDURAL",
        "INFILTRATION",
        "INTRACAUDAL",
        "PERINEURAL"
      ],
      "update_date": "08/04/2026",
      "initial_posting_date": "02/20/2018",
      "source_url": "https://api.fda.gov/drug/shortages.json"
    },
    {
      "package_ndc": "63323-462-37",
      "product_ndc": "63323-460",
      "company_name": "Fresenius Kabi USA, LLC",
      "manufacturer_name": "Fresenius Kabi USA, LLC",
      "presentation": "Sensorcaine, Injection, 5 mg/1 mL; .005 mg/1 mL (NDC 63323-462-37)",
      "availability": "Available",
      "dosage_form": "Injection",
      "routes": [
        "EPIDURAL",
        "INFILTRATION",
        "INTRACAUDAL",
        "PERINEURAL"
      ],
      "update_date": "08/04/2026",
      "initial_posting_date": "02/20/2018",
      "source_url": "https://api.fda.gov/drug/shortages.json"
    },
    {
      "package_ndc": "63323-463-57",
      "product_ndc": "63323-461",
      "company_name": "Fresenius Kabi USA, LLC",
      "manufacturer_name": "Fresenius Kabi USA, LLC",
      "presentation": "Sensorcaine, Injection, 5 mg/1 mL; .005 mg/1 mL (NDC 63323-463-57)",
      "availability": "Available",
      "dosage_form": "Injection",
      "routes": [
        "PERINEURAL"
      ],
      "update_date": "08/04/2026",
      "initial_posting_date": "02/20/2018",
      "source_url": "https://api.fda.gov/drug/shortages.json"
    },
    {
      "package_ndc": "63323-460-37",
      "product_ndc": "63323-460",
      "company_name": "Fresenius Kabi USA, LLC",
      "manufacturer_name": "Fresenius Kabi USA, LLC",
      "presentation": "Sensorcaine, Injection, 7.5 mg/1 mL; .005 mg/1 mL (NDC 63323-460-37)",
      "availability": "Available",
      "dosage_form": "Injection",
      "routes": [
        "EPIDURAL",
        "RETROBULBAR"
      ],
      "update_date": "08/04/2026",
      "initial_posting_date": "02/20/2018",
      "source_url": "https://api.fda.gov/drug/shortages.json"
    },
    {
      "package_ndc": "0409-9042-01",
      "product_ndc": "0409-1159",
      "company_name": "Hospira, Inc., a Pfizer Company",
      "manufacturer_name": "Hospira, Inc.",
      "presentation": "Bupivacaine Hydrochloride And Epinephrine, Injection, 25 mg/10 mL (2.5 mg/mL) (NDC 0409-9042-01)",
      "availability": "Unavailable",
      "dosage_form": "Injection",
      "routes": [
        "EPIDURAL",
        "INFILTRATION",
        "INTRACAUDAL",
        "PERINEURAL"
      ],
      "update_date": "08/07/2026",
      "initial_posting_date": "02/20/2018",
      "source_url": "https://api.fda.gov/drug/shortages.json"
    },
    {
      "package_ndc": "0409-9046-01",
      "product_ndc": "0409-1159",
      "company_name": "Hospira, Inc., a Pfizer Company",
      "manufacturer_name": "Hospira, Inc.",
      "presentation": "Bupivacaine Hydrochloride And Epinephrine, Injection, 250 mg/50 mL (5 mg/mL) (NDC 0409-9046-01)",
      "availability": "Unavailable",
      "dosage_form": "Injection",
      "routes": [
        "PERINEURAL"
      ],
      "update_date": "08/07/2026",
      "initial_posting_date": "02/20/2018",
      "source_url": "https://api.fda.gov/drug/shortages.json"
    },
    {
      "package_ndc": "0409-9045-01",
      "product_ndc": "0409-1159",
      "company_name": "Hospira, Inc., a Pfizer Company",
      "manufacturer_name": "Hospira, Inc.",
      "presentation": "Bupivacaine Hydrochloride And Epinephrine, Injection, 50 mg/10 mL (5 mg/mL) (NDC 0409-9045-01)",
      "availability": "Unavailable",
      "dosage_form": "Injection",
      "routes": [
        "EPIDURAL",
        "INTRACAUDAL",
        "PERINEURAL"
      ],
      "update_date": "08/07/2026",
      "initial_posting_date": "02/20/2018",
      "source_url": "https://api.fda.gov/drug/shortages.json"
    },
    {
      "package_ndc": "0409-9042-17",
      "product_ndc": "0409-1159",
      "company_name": "Hospira, Inc., a Pfizer Company",
      "manufacturer_name": "Hospira, Inc.",
      "presentation": "Bupivacaine Hydrochloride And Epinephrine, Injection, 75 mg/30 mL (2.5 mg/mL) (NDC 0409-9042-17)",
      "availability": "Unavailable",
      "dosage_form": "Injection",
      "routes": [
        "EPIDURAL",
        "INFILTRATION",
        "INTRACAUDAL",
        "PERINEURAL"
      ],
      "update_date": "08/07/2026",
      "initial_posting_date": "02/20/2018",
      "source_url": "https://api.fda.gov/drug/shortages.json"
    },
    {
      "package_ndc": "0409-9043-01",
      "product_ndc": "0409-1159",
      "company_name": "Hospira, Inc., a Pfizer Company",
      "manufacturer_name": "Hospira, Inc.",
      "presentation": "Bupivacaine Hydrochloride and Epinephrine, Injection, 125 mg/50 mL (2.5 mg/mL) (NDC 0409-9043-01)",
      "availability": "Unavailable",
      "dosage_form": "Injection",
      "routes": [
        "INFILTRATION",
        "PERINEURAL"
      ],
      "update_date": "08/07/2026",
      "initial_posting_date": "02/20/2018",
      "source_url": "https://api.fda.gov/drug/shortages.json"
    },
    {
      "package_ndc": "0409-9045-17",
      "product_ndc": "0409-1159",
      "company_name": "Hospira, Inc., a Pfizer Company",
      "manufacturer_name": "Hospira, Inc.",
      "presentation": "Bupivacaine Hydrochloride and Epinephrine, Injection, 150 mg/30 mL (5 mg/mL) (NDC 0409-9045-17)",
      "availability": "Unavailable",
      "dosage_form": "Injection",
      "routes": [
        "EPIDURAL",
        "INTRACAUDAL",
        "PERINEURAL"
      ],
      "update_date": "08/07/2026",
      "initial_posting_date": "02/20/2018",
      "source_url": "https://api.fda.gov/drug/shortages.json"
    },
    {
      "package_ndc": "0409-1752-50",
      "product_ndc": "0409-0525",
      "company_name": "Hospira, Inc., a Pfizer Company",
      "manufacturer_name": "Hospira, Inc.",
      "presentation": "Marcaine With Epinephrine, Injection, Marcaine with Epinephrine 1:200,000 as the bitartrate 125 mg/50 mL (2.5 mg/mL 1:200,000) (NDC 0409-1752-50)",
      "availability": "Available",
      "dosage_form": "Injection",
      "routes": [
        "INFILTRATION",
        "PERINEURAL"
      ],
      "update_date": "08/07/2026",
      "initial_posting_date": "02/20/2018",
      "source_url": "https://api.fda.gov/drug/shortages.json"
    },
    {
      "package_ndc": "0409-1749-29",
      "product_ndc": "0409-0525",
      "company_name": "Hospira, Inc., a Pfizer Company",
      "manufacturer_name": "Hospira, Inc.",
      "presentation": "Marcaine With Epinephrine, Injection, Marcaine with Epinephrine 1:200,000 as the bitartrate 150 mg/30 mL (5 mg/mL 1:200,000) (NDC 0409-1749-29)",
      "availability": "Available",
      "dosage_form": "Injection",
      "routes": [
        "EPIDURAL",
        "INTRACAUDAL",
        "PERINEURAL"
      ],
      "update_date": "08/07/2026",
      "initial_posting_date": "02/20/2018",
      "source_url": "https://api.fda.gov/drug/shortages.json"
    },
    {
      "package_ndc": "0409-1746-10",
      "product_ndc": "0409-0525",
      "company_name": "Hospira, Inc., a Pfizer Company",
      "manufacturer_name": "Hospira, Inc.",
      "presentation": "Marcaine With Epinephrine, Injection, Marcaine with Epinephrine 1:200,000 as the bitartrate 25 mg/10 mL (2.5 mg/mL 1:200,000) (NDC 0409-1746-10)",
      "availability": "Available",
      "dosage_form": "Injection",
      "routes": [
        "EPIDURAL",
        "INFILTRATION",
        "INTRACAUDAL",
        "PERINEURAL"
      ],
      "update_date": "08/07/2026",
      "initial_posting_date": "02/20/2018",
      "source_url": "https://api.fda.gov/drug/shortages.json"
    },
    {
      "package_ndc": "0409-1755-50",
      "product_ndc": "0409-0525",
      "company_name": "Hospira, Inc., a Pfizer Company",
      "manufacturer_name": "Hospira, Inc.",
      "presentation": "Marcaine With Epinephrine, Injection, Marcaine with Epinephrine 1:200,000 as the bitartrate 250 mg/50 mL (5 mg/mL 1:200,000) (NDC 0409-1755-50)",
      "availability": "Available",
      "dosage_form": "Injection",
      "routes": [
        "PERINEURAL"
      ],
      "update_date": "08/07/2026",
      "initial_posting_date": "02/20/2018",
      "source_url": "https://api.fda.gov/drug/shortages.json"
    },
    {
      "package_ndc": "0409-1749-10",
      "product_ndc": "0409-0525",
      "company_name": "Hospira, Inc., a Pfizer Company",
      "manufacturer_name": "Hospira, Inc.",
      "presentation": "Marcaine With Epinephrine, Injection, Marcaine with Epinephrine 1:200,000 as the bitartrate 50 mg/10 mL (5 mg/mL 1:200,000) (NDC 0409-1749-10)",
      "availability": "Available",
      "dosage_form": "Injection",
      "routes": [
        "EPIDURAL",
        "INTRACAUDAL",
        "PERINEURAL"
      ],
      "update_date": "08/07/2026",
      "initial_posting_date": "02/20/2018",
      "source_url": "https://api.fda.gov/drug/shortages.json"
    },
    {
      "package_ndc": "0409-1746-30",
      "product_ndc": "0409-0525",
      "company_name": "Hospira, Inc., a Pfizer Company",
      "manufacturer_name": "Hospira, Inc.",
      "presentation": "Marcaine With Epinephrine, Injection, Marcaine with Epinephrine 1:200,000 as the bitartrate 75 mg/30 mL (2.5 mg/mL 1:200,000) (NDC 0409-1746-30)",
      "availability": "Available",
      "dosage_form": "Injection",
      "routes": [
        "EPIDURAL",
        "INFILTRATION",
        "INTRACAUDAL",
        "PERINEURAL"
      ],
      "update_date": "08/07/2026",
      "initial_posting_date": "02/20/2018",
      "source_url": "https://api.fda.gov/drug/shortages.json"
    }
  ],
  "availability_counts": {
    "Available": 12,
    "Unavailable": 8
  },
  "initial_posting_date": "02/20/2018",
  "latest_source_update": "08/07/2026",
  "source_updated_at": "2026-08-22",
  "official_url": "https://api.fda.gov/drug/shortages.json",
  "source_name": "U.S. Food and Drug Administration openFDA Drug Shortages",
  "source_license_url": "https://open.fda.gov/license/",
  "retrieved_at": "2026-08-22T15:54:11+00:00",
  "unknowns": {
    "local_availability": "Unknown. FDA status is nationwide and is not local inventory.",
    "clinical_alternatives": "Not provided. CiteFacts does not publish treatment or substitution advice.",
    "resolution_date": "Unknown unless an FDA source row provides an update date."
  },
  "derivations": {
    "status": "current when a grouped FDA row has Current; otherwise it preserves the available FDA Resolved, Discontinuation, or not-current state.",
    "ingredient_page": "Grouped by FDA generic_name, falling back to openFDA.generic_name.",
    "availability_counts": "Count of non-empty FDA package availability values; it is not a claim about local supply."
  }
}